The emergence of Multiple Drug Resistant (MDR) pathogenic bacteria has lessened the effectiveness of antibiotic drugs. Bacteriophage Therapy has the best potential to act against MDR bacteria with much lower side effects.
Biofilm formation is responsible for about 65% of all microbial infections and 80% of all chronic infections. A greater understanding of bacterial biofilm is thus needed for the development of novel and effective control strategies for improvement in patient management and enhancing the clinical decision-making process.
Structural conversion of soluble proteins to self-associating conformations leads to formation of macromolecular insoluble fibrillar aggregates called amyloids. Majority of functional amyloids in bacteria perform physiological tasks on the cell surface such as biofilm formation, adhesion, invasion of host cells, and host–pathogen interactions.